review Open AccessTop 1% cited
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
Molecular Cell · 2017 · Vol. 66(6) · pp. 801–817
Andrew N. Blackford✉(John Radcliffe Hospital)Stephen P. Jackson✉(Wellcome/Cancer Research UK Gurdon Institute)
DNA Repair MechanismsCRISPR and Genetic EngineeringCarcinogens and Genotoxicity AssessmentBiologyDNADNA damageCell biologyGeneticsComputational biologyMolecular biology
MeSH terms
AnimalsAntineoplastic AgentsCalcium-Binding ProteinsCell NucleusDNA DamageDNA RepairEnzyme ActivationHumansModels, MolecularNeoplasmsPhosphorylationProtein ConformationStructure-Activity RelationshipSignal TransductionTumor Suppressor Protein p53
Funding
- Cancer Research UK
- University of Cambridge
Citations
1,904
FWCI
59.55
field-weighted impact
References
271
Percentile
100%
vs. same field & year
Citations per year
References
DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139
Journal of Biological Chemistry · 1998 · 5,347 citations
The DNA Damage Response: Making It Safe to Play with Knives
Molecular Cell · 2010 · 4,258 citations
Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
Molecular Cell · 2012 · 1,627 citations
Development and Applications of CRISPR-Cas9 for Genome Engineering
Cell · 2014 · 5,789 citations
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
Molecular and Cellular Biology · 2001 · 1,072 citations
Hallmarks of Cancer: The Next Generation
Cell · 2011 · 65,668 citations
Chk1 is an essential kinase that is regulated by Atr and required for the G<sub>2</sub>/M DNA damage checkpoint
Genes & Development · 2000 · 1,613 citations
Targeting the DNA Damage Response in Cancer
Molecular Cell · 2015 · 1,490 citations
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