NOD-2 like receptor expression in psoriatic skin

Abstract

Psoriasis is a long-lasting, widespread disease characterized by inflammation throughout the body, caused by the immune system, and it affects approximately 2% of the population. The disease known as psoriasis is a complicated condition that is caused by a number of genes and is affected by both genetic and environmental factor factors. Inflammatory responses to bacterial psoriasis are influenced by NOD2, which is a member of the NOD1/APAF1 family of apoptosis genes and plays a role in producing these responses. The activation of the transcription factor NFκB is responsible for the regulation of these responses. The NOD2 receptor is an intracellular receptor that is capable of recognizing microbial components that are derived from peptidoglycan found in bacteria. Furthermore, it has the potential to cause inflammation in the mucosal tissues, in addition to its role in maintaining the equilibrium of the mucosal environment where it is found.