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The Ratio of Blood Products Transfused Affects Mortality in Patients Receiving Massive Transfusions at a Combat Support Hospital

The Journal of Trauma: Injury, Infection, and Critical Care · 2007 · Vol. 63(4) · pp. 805–813
Matthew A. Borgman✉Philip C. SpinellaJeremy G. PerkinsKurt W. GrathwohlThomas B. RepineAlec C. BeekleyJames SebestaDonald H. JenkinsCharles E. WadeJohn B. Holcomb
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Abstract

In patients with combat-related trauma requiring massive transfusion, a high 1:1.4 plasma to RBC ratio is independently associated with improved survival to hospital discharge, primarily by decreasing death from hemorrhage. For practical purposes, massive transfusion protocols should utilize a 1:1 ratio of plasma to RBCs for all patients who are hypocoagulable with traumatic injuries.

Trauma, Hemostasis, Coagulopathy, ResuscitationTrauma and Emergency Care StudiesBlood transfusion and managementInterquartile rangeMedicineOdds ratioCoagulopathyConfidence intervalInjury Severity ScoreBlood transfusionInternal medicinePopulationSurgery

MeSH terms

AdultCause of DeathFemaleHemorrhageHospitals, MilitaryHumansIraqMaleOutcome and Process Assessment, Health CarePlasmaRetrospective StudiesWounds and InjuriesInjury Severity ScoreComorbidityMultivariate Analysis
Citations
1,580
FWCI
56.48
field-weighted impact
References
78
Percentile
100%
vs. same field & year
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References
Acute Traumatic Coagulopathy
The Journal of Trauma: Injury, Infection, and Critical Care · 2003 · 1,708 citations
Blood Transfusion, Independent of Shock Severity, Is Associated with Worse Outcome in Trauma
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Fresh Frozen Plasma Should be Given Earlier to Patients Requiring Massive Transfusion
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Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma
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Blood Transfusion
Archives of Surgery · 1997 · 565 citations
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