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The Ratio of Fibrinogen to Red Cells Transfused Affects Survival in Casualties Receiving Massive Transfusions at an Army Combat Support Hospital
The Journal of Trauma: Injury, Infection, and Critical Care · 2008 · Vol. 64(2) · pp. S79–S85
Harry K. Stinger✉(United States Army Institute of Surgical Research)Philip C. Spinella(S.P.E.C.I.E.S.)Jeremy G. Perkins(S.P.E.C.I.E.S.)Kurt W. Grathwohl(S.P.E.C.I.E.S.)José Salinas(United States Army)Wenjun Z. Martini(United States Army)John R. Hess(United States Army)Michael A. Dubick(S.P.E.C.I.E.S.)Clayton D. Simon(United States Army)Alec C. Beekley(United States Army)Steven E. Wolf(S.P.E.C.I.E.S.)Charles E. Wade(S.P.E.C.I.E.S.)John B. Holcomb(S.P.E.C.I.E.S.)
Abstract
In patients with combat-related trauma requiring massive transfusion, the transfusion of an increased fibrinogen: RBC ratio was independently associated with improved survival to hospital discharge, primarily by decreasing death from hemorrhage. Prospective studies are needed to evaluate the best source of fibrinogen and the optimal empiric ratio of fibrinogen to RBCs in patients requiring massive transfusion.
Trauma, Hemostasis, Coagulopathy, ResuscitationTrauma and Emergency Care StudiesAbdominal Trauma and InjuriesFibrinogenCryoprecipitateMedicineCoagulopathyBlood transfusionInternal medicineBlood productHemoglobinSurgery
MeSH terms
Erythrocyte CountFibrinogenHospitals, MilitaryHumansRetrospective StudiesROC CurveUnited StatesWounds and InjuriesCohort StudiesInjury Severity ScoreSurvival RateErythrocyte TransfusionIraq War, 2003-2011
Citations
412
FWCI
18.30
field-weighted impact
References
54
Percentile
99%
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References
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Hemostatic Factors and Replacement of Major Blood Loss with Plasma-Poor Red Cell Concentrates
Anesthesia & Analgesia · 1995 · 659 citations
Blood Transfusion, Independent of Shock Severity, Is Associated with Worse Outcome in Trauma
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Fresh Frozen Plasma Should be Given Earlier to Patients Requiring Massive Transfusion
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Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma
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Massive Transfusion Practices Around the Globe and a Suggestion for a Common Massive Transfusion Protocol
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