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Massive Transfusion Practices Around the Globe and a Suggestion for a Common Massive Transfusion Protocol
The Journal of Trauma: Injury, Infection, and Critical Care · 2006 · Vol. 60(6) · pp. S91–S96
Debra L. Malone✉(University of Maryland Medical Center)John R. Hess(Dystrophic Epidermolysis Bullosa Research Association of America)Abe Fingerhut(Dystrophic Epidermolysis Bullosa Research Association of America)
Abstract
The evidence would suggest that prevention of coagulopathy is superior to its treatment. Simple ratios such as 1:1:1 RBC:plasma:platelets have the benefit of ease of use and the relatively higher plasma and platelet doses appear to be associated with improved outcome. Such a standard protocol can foster multicenter research on resuscitation and hemorrhage control. The fixed volume ratios might allow the number and rate of administered units of RBC to be used as surrogates for blood loss and primary treatment effect.
Trauma, Hemostasis, Coagulopathy, ResuscitationTrauma and Emergency Care StudiesBlood transfusion and managementCoagulopathyMedicineIntensive care medicineProtocol (science)Blood transfusionFresh frozen plasmaResuscitationEmergency medicinePlateletAnesthesia
MeSH terms
AustraliaBlood Coagulation DisordersBlood TransfusionFinlandFranceHumansPractice Patterns, Physicians'Trauma CentersUnited StatesWounds and InjuriesPractice Guidelines as TopicTransfusion Reaction
Citations
447
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References
Recombinant Factor VIIa as Adjunctive Therapy for Bleeding Control in Severely Injured Trauma Patients: Two Parallel Randomized, Placebo-Controlled, Double-Blind Clinical Trials
The Journal of Trauma: Injury, Infection, and Critical Care · 2005 · 782 citations
Practice Guidelines for Blood Component Therapy
Anesthesiology · 1996 · 757 citations
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