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The Relationship of Blood Product Ratio to Mortality: Survival Benefit or Survival Bias?
The Journal of Trauma: Injury, Infection, and Critical Care · 2009 · Vol. 66(2) · pp. 358–364
Christopher W. Snyder✉(University of Alabama at Birmingham)Jordan A. Weinberg(University of Alabama at Birmingham)Gerald McGwin(University of Alabama)Sherry M. Melton(University of Alabama)Richard L. George(University of Alabama at Birmingham)Donald A. Reiff(University of Alabama)James M. Cross(University of Alabama)Jennifer Hubbard-Brown(University of Alabama)Loring W. Rue(University of Alabama)Jeffrey D. Kerby(University of Alabama)
Abstract
Similar to previous studies, an association between higher FFP:PRBC ratios at 24 hours and improved survival was observed. However, after adjustment for survival bias in the analysis, the association was no longer statistically significant. Prospective trials are necessary to evaluate whether hemostatic resuscitation is clinically beneficial.
Trauma, Hemostasis, Coagulopathy, ResuscitationBlood donation and transfusion practicesRenal function and acid-base balanceMedicineFresh frozen plasmaBlood productConfidence intervalRelative riskInternal medicineSurgery
MeSH terms
AdultCross-Sectional StudiesFemaleHumansMalePlasmaRegression AnalysisResuscitationTime FactorsChi-Square DistributionSurvival AnalysisTreatment OutcomeHospital MortalityErythrocyte Transfusion
Citations
389
FWCI
29.33
field-weighted impact
References
26
Percentile
100%
vs. same field & year
Citations per year
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References
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The Journal of Trauma: Injury, Infection, and Critical Care · 2008 · 413 citations
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