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Increased Plasma and Platelet to Red Blood Cell Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients
Annals of Surgery · 2008 · Vol. 248(3) · pp. 447–458
John B. Holcomb✉(Connecticut Children's Medical Center)Charles E. Wade✉(United States Army Institute of Surgical Research)Joel Michalek(The University of Texas Health Science Center at San Antonio)Gary B. Chisholm(The University of Texas Health Science Center at San Antonio)Lee Ann Zarzabal(The University of Texas Health Science Center at San Antonio)Martin A. Schreiber(Oregon Health & Science University)Ernest A. Gonzalez(The University of Texas Health Science Center at Houston)Gregory J. Pomper(Wake Forest University)Jeremy G. PerkinsPhilip C. Spinella✉(United States Army Institute of Surgical Research)Kari Williams✉(United States Army Institute of Surgical Research)Myung S. Park✉(United States Army Institute of Surgical Research)
Abstract
Current transfusion practices and survival rates of MT patients vary widely among trauma centers. Conventional MT guidelines may underestimate the optimal plasma and platelet to RBC ratios. Survival in civilian MT patients is associated with increased plasma and platelet ratios. Massive transfusion practice guidelines should aim for a 1:1:1 ratio of plasma:platelets:RBCs.
Trauma, Hemostasis, Coagulopathy, ResuscitationTrauma and Emergency Care StudiesAbdominal Trauma and InjuriesMedicineTrauma centerPlateletInjury Severity ScoreRed blood cellBlood productMajor traumaBlood transfusionInternal medicineRetrospective cohort study
MeSH terms
AdultFemaleHemorrhageHumansMaleMiddle AgedPlasmaRetrospective StudiesTrauma CentersWounds and InjuriesSurvival AnalysisBlood Component TransfusionErythrocyte TransfusionPlatelet Transfusion
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