reviewTop 1% cited
The BCL-2 protein family: opposing activities that mediate cell death
Nature Reviews Molecular Cell Biology · 2007 · Vol. 9(1) · pp. 47–59
Richard J. Youle✉(National Institute of Neurological Disorders and Stroke)Andreas Strasser(Walter and Eliza Hall Institute of Medical Research)
Cell death mechanisms and regulationRNA Interference and Gene DeliverySignaling Pathways in DiseaseBiologyBcl-2 familyCarcinogenesisProgrammed cell deathApoptosisCaspaseProtein familyCell biologyMechanism (biology)Cell fate determination
MeSH terms
AnimalsHumansMitochondriaModels, MolecularPhylogenyApoptosisProtein Structure, TertiaryProto-Oncogene Proteins c-bcl-2
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References
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Current Biology · 2000 · 965 citations
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Cell Death and Differentiation · 2006 · 605 citations
The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues
Molecular Cell · 2000 · 1,468 citations
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Cell · 1998 · 4,423 citations
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
Cancer Cell · 2006 · 1,253 citations
PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
Molecular Cell · 2001 · 1,277 citations
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