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Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Cell · 1998 · Vol. 94(4) · pp. 491–501
Honglin Li✉(Harvard University)Hong Zhu(Harvard University)Chi-jie Xu(Harvard University)Junying Yuan(Harvard University)
Cell death mechanisms and regulationMitochondrial Function and PathologyCell biologyBiologyMitochondrionMitochondrial apoptosis-induced channelCytochrome cCaspaseApoptosisCytosolCytoplasmMediator
MeSH terms
AnimalsCarrier ProteinsCell NucleusCysteine EndopeptidasesCytochrome c GroupHumansMitochondriaPeptide FragmentsSubstrate SpecificityTumor Necrosis Factor-alphaSignal TransductionApoptosisfas ReceptorProto-Oncogene Proteins c-bcl-2Caspases
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References
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
The EMBO Journal · 1995 · 2,138 citations
Two CD95 (APO-1/Fas) signaling pathways
The EMBO Journal · 1998 · 2,997 citations
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
The EMBO Journal · 1998 · 1,231 citations
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Cell · 1997 · 7,227 citations
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
The Journal of Cell Biology · 1997 · 1,800 citations
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Cell · 1996 · 5,154 citations
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
Journal of Biological Chemistry · 1997 · 2,071 citations
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