article Open AccessTop 1% cited
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
Cancer Cell · 2002 · Vol. 2(3) · pp. 183–192
Anthony Letai(Howard Hughes Medical Institute)Michael C. Bassik(Howard Hughes Medical Institute)Loren D. Walensky(Howard Hughes Medical Institute)Mia D. Sorcinelli(Howard Hughes Medical Institute)Solly Weiler(Howard Hughes Medical Institute)Stanley J. Korsmeyer✉(Howard Hughes Medical Institute)
ATP Synthase and ATPases ResearchCell death mechanisms and regulationMitochondrial Function and PathologyApoptosisCancer cellMitochondrionCancerCell biologyCancer researchProgrammed cell deathBiologyChemistryGenetics
MeSH terms
Bcl-2-Like Protein 11AnimalsCarrier ProteinsCytochrome c GroupHumansMembrane ProteinsMitochondriaProto-Oncogene ProteinsTransduction, GeneticApoptosisProtein Structure, TertiaryJurkat CellsProto-Oncogene Proteins c-bcl-2bcl-2 Homologous Antagonist-Killer ProteinApoptosis Regulatory Proteins
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References
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Oncogene · 1998 · 1,055 citations
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Cell · 1998 · 4,423 citations
The Bcl-2 Protein Family
Experimental Cell Research · 2000 · 791 citations
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
The Journal of Cell Biology · 1997 · 1,800 citations
Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane
Molecular and Cellular Biology · 2000 · 1,203 citations
Bim: a novel member of the Bcl-2 family that promotes apoptosis
The EMBO Journal · 1998 · 1,151 citations
BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis
Molecular Cell · 2001 · 1,688 citations
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