article Open AccessTop 1% cited
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
Cancer Cell · 2006 · Vol. 9(5) · pp. 351–365
Michael Certo✉(Dana-Farber Cancer Institute)Victoria Del Gaizo Moore(Dana-Farber Cancer Institute)Mari Nishino(Dana-Farber Cancer Institute)Guo Wei(Dana-Farber Cancer Institute)Stanley J. Korsmeyer(Dana-Farber Cancer Institute)Scott A. Armstrong(Boston Children's Hospital)Anthony Letai(Dana-Farber Cancer Institute)
Cell death mechanisms and regulationApoptosisBcl-2 familyMitochondrionActivator (genetics)Cell biologyPriming (agriculture)Programmed cell deathBiologyReceptorBiochemistry
MeSH terms
Bcl-2-Like Protein 11Amino Acid SequenceAnimalsBiphenyl CompoundsIntracellular MembranesLeukemiaMembrane ProteinsMitochondria, LiverMolecular Sequence DataNitrophenolsPeptide FragmentsPiperazinesProtein BindingProto-Oncogene ProteinsSulfonamides
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References
Cell Death
Cell · 2004 · 4,620 citations
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
Cancer Cell · 2002 · 1,634 citations
PUMA, a Novel Proapoptotic Gene, Is Induced by p53
Molecular Cell · 2001 · 2,283 citations
The Hallmarks of Cancer
Cell · 2000 · 28,385 citations
Bim: a novel member of the Bcl-2 family that promotes apoptosis
The EMBO Journal · 1998 · 1,151 citations
Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function
Molecular Cell · 2005 · 1,794 citations
BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis
Molecular Cell · 2001 · 1,688 citations
A matter of life and death
Cancer Cell · 2002 · 1,236 citations
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