article Open AccessTop 1% cited
<scp>GSDMD</scp> membrane pore formation constitutes the mechanism of pyroptotic cell death
The EMBO Journal · 2016 · Vol. 35(16) · pp. 1766–1778
Lorenzo Sborgi✉(University of Basel)Sebastian Rühl(University of Basel)Estefania Mulvihill(Board of the Swiss Federal Institutes of Technology)Joka Pipercevic(University of Basel)Rosalie Heilig(University of Basel)Henning Stahlberg(University of Basel)Christopher J. Farady(Novartis (Switzerland))Daniel J. Müller(Board of the Swiss Federal Institutes of Technology)Petr Brož(University of Basel)Sebastian Hiller(University of Basel)
Inflammasome and immune disordersCell death mechanisms and regulationStreptococcal Infections and TreatmentsBiologyMechanism (biology)Cell biologyProgrammed cell deathBiophysicsCell membraneMembraneBiochemistryApoptosis
MeSH terms
PyroptosisGasderminsCell LineCell MembraneHumansLiposomesNeoplasm ProteinsPermeabilityMicroscopy, Atomic ForceCaspase 1Cryoelectron MicroscopyPhosphate-Binding ProteinsIntracellular Signaling Peptides and Proteins
Funding
- National Science Foundation
- Marie Curie
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- European Research Council
- FP7 People: Marie-Curie Actions
Citations
1,131
FWCI
43.34
field-weighted impact
References
45
Percentile
100%
vs. same field & year
Citations per year
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References
Activation and regulation of the inflammasomes
Nature reviews. Immunology · 2013 · 2,842 citations
The BCL-2 protein family: opposing activities that mediate cell death
Nature Reviews Molecular Cell Biology · 2007 · 4,586 citations
Pyroptosis: host cell death and inflammation
Nature Reviews Microbiology · 2009 · 3,189 citations
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
Cell Reports · 2014 · 805 citations
Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3
Molecular Cell · 2014 · 1,542 citations
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Nature Cell Biology · 2013 · 1,307 citations
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
Nature Immunology · 2010 · 1,324 citations
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