Shizuo Akira

Osaka UniversityORCID https://orcid.org/0000-0001-7602-9617

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Publications

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Citations

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i10-index

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Impact (2-yr)

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Top Publications

Pathogen Recognition and Innate Immunity

Cell200611,743 citationsFirst authorCorresponding

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Nature Immunology20108,950 citations

Pattern Recognition Receptors and Inflammation

Cell20108,539 citations

Toll-like receptor signalling

Nature reviews. Immunology20048,188 citationsFirst authorCorresponding

Toll-Like Receptors

Annual Review of Immunology20036,131 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

Nature Immunology20014,755 citationsFirst authorCorresponding

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Nature Immunology20043,850 citations

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

Immunity20113,568 citationsCorresponding

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

The Journal of Immunology19993,357 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Immunity19993,351 citationsCorresponding

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Nature Immunology20052,532 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Nature Immunology20022,484 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

Immunity19992,066 citationsCorresponding

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

Immunity19982,015 citationsCorresponding

Innate immune recognition of viral infection

Nature Immunology20061,871 citations

Autophagy in infection, inflammation and immunity

Nature reviews. Immunology20131,849 citations

TLR signaling

Cell Death and Differentiation20061,757 citations

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

The Journal of Immunology20051,640 citations

Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2

The Journal of Experimental Medicine20031,620 citations

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

The Journal of Experimental Medicine20081,542 citations

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

The Journal of Experimental Medicine20061,509 citations

Toll-like receptors control activation of adaptive immune responses

Nature Immunology20011,361 citations

Cell Type-Specific Involvement of RIG-I in Antiviral Response

Immunity20051,338 citationsCorresponding

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)

The FASEB Journal19901,315 citationsFirst authorCorresponding

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

The Journal of Immunology20021,312 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

The Journal of Immunology20021,222 citations

Innate immunity to virus infection

Immunological Reviews20081,214 citations

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

Nature Cell Biology20091,189 citations

Toll-like receptors and innate immunity

Biochemical and Biophysical Research Communications20091,162 citationsCorresponding

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

The Journal of Immunology20011,088 citations

Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection

The Journal of Immunology20001,046 citations

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

Journal of Virology20071,038 citations

Toll‐like Receptor and RIG‐1‐like Receptor Signaling

Annals of the New York Academy of Sciences2008965 citations

Toll-like receptor function and signaling

Journal of Allergy and Clinical Immunology2006886 citationsCorresponding

Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α+ DC correlates with unresponsiveness to imidazoquinolines

European Journal of Immunology2003535 citations

The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

European Journal of Immunology2003515 citations