articleTop 1% cited

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Nature Immunology · 2002 · Vol. 3(2) · pp. 196–200

Hiroaki Hemmi✉(Osaka University)Tsuneyasu Kaisho(Osaka University)Osamu Takeuchi(Osaka University)Shintaro Sato(Osaka University)Hideki Sanjo(Osaka University)Katsuaki Hoshino(Osaka University)Takao Horiuchi(Osaka University)Hideyuki Tomizawa(Japan Petroleum Energy Center)Kiyoshi Takeda(Osaka University)Shizuo Akira(Osaka University)

View via DOI Publisher page

Immune Response and Inflammation Immune Cell Function and Interaction Immunotherapy and Immune ResponsesTLR7Immune systemCell biologySignal transductionToll-like receptorCytokineBiologySplenocyteChemistryInnate immune system

MeSH terms

ImiquimodAdjuvants, ImmunologicAminoquinolinesAnimalsAntigens, DifferentiationAntiviral AgentsBone Marrow CellsDendritic CellsImidazolesInterferon InducersMembrane GlycoproteinsMice, Mutant StrainsReceptors, Cell SurfaceReceptors, ImmunologicSpleen

Citations

2,484

FWCI

42.18

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

Microglia Initiate Central Nervous System Innate and Adaptive Immune Responses through Multiple TLRs

The Journal of Immunology · 2004 · 1,207 citations

Toll-Like Receptors

Annual Review of Immunology · 2003 · 6,131 citations

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

Journal of General Virology · 2007 · 1,551 citations

How we detect microbes and respond to them: the Toll-like receptors and their transducers

Journal of Leukocyte Biology · 2003 · 593 citations

Endogenous ligands of Toll-like receptors

Journal of Leukocyte Biology · 2004 · 681 citations

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

Clinical Microbiology Reviews · 2009 · 3,020 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

The Journal of Immunology · 2002 · 1,222 citations

Toll-like receptors and innate immunity

Biochemical and Biophysical Research Communications · 2009 · 1,162 citations

References

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

Nature Immunology · 2000 · 1,662 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

Nature Immunology · 2001 · 4,755 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

The Journal of Immunology · 1999 · 3,357 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

Immunity · 1999 · 2,066 citations

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

European Journal of Immunology · 2001 · 775 citations

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

Journal of Biological Chemistry · 1999 · 1,956 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Immunity · 1999 · 3,351 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

Immunity · 1998 · 2,015 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.