reviewTop 1% cited
Toll-like receptors: critical proteins linking innate and acquired immunity
Nature Immunology · 2001 · Vol. 2(8) · pp. 675–680
Shizuo Akira✉(Osaka University)Kiyoshi Takeda(Japan Science and Technology Agency)Tsuneyasu Kaisho(Japan Science and Technology Agency)
Immune Response and InflammationNF-κB Signaling PathwaysAntimicrobial Peptides and ActivitiesReceptorPattern recognition receptorInnate immune systemBiologyCell biologySignal transductionTumor necrosis factor alphaImmune receptorFunction (biology)Toll-like receptor
MeSH terms
AnimalsHumansImmunityInterleukin-1Membrane GlycoproteinsReceptors, Cell SurfaceSignal TransductionReceptors, Interleukin-1Drosophila ProteinsToll-Like Receptors
Citations
4,755
FWCI
77.22
field-weighted impact
References
85
Percentile
100%
vs. same field & year
Citations per year
Cited by
Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation
American Journal of Physiology-Gastrointestinal and Liver Physiology · 2002 · 478 citations
Toll-Like Receptors 3 and 4 Are Expressed by Human Bone Marrow-Derived Mesenchymal Stem Cells and Can Inhibit Their T-Cell Modulatory Activity by Impairing Notch Signaling
Stem Cells · 2007 · 483 citations
<i>Helicobacter pylori</i>and Gastric Cancer: Factors That Modulate Disease Risk
Clinical Microbiology Reviews · 2010 · 1,422 citations
The Role of Macrophages in Cancer Development and Therapy
Cancers · 2021 · 314 citations
Toll-Like Receptors
Annual Review of Immunology · 2003 · 6,131 citations
Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials
Materials · 2015 · 657 citations
Interleukin-18
Journal of Leukocyte Biology · 2003 · 598 citations
Inflammatory responses and inflammation-associated diseases in organs
Oncotarget · 2017 · 4,861 citations
References
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
Nature Immunology · 2000 · 1,662 citations
Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex
The Journal of Immunology · 2000 · 1,606 citations
Dendritic cells and the control of immunity
Nature · 1998 · 14,273 citations
Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells
The Journal of Immunology · 2000 · 1,050 citations
Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product
The Journal of Immunology · 1999 · 3,357 citations
Unresponsiveness of MyD88-Deficient Mice to Endotoxin
Immunity · 1999 · 2,066 citations
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Molecular Cell · 1998 · 1,557 citations
Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
Immunity · 1999 · 3,351 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.