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Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

Immunity · 1998 · Vol. 9(1) · pp. 143–150

Osamu Adachi(Japan Science and Technology Agency)Taro Kawai(Hyogo Medical University)Kiyoshi Takeda(Hyogo Medical University)Makoto Matsumoto(Hyogo Medical University)Hiroko Tsutsui(Japan Science and Technology Agency)Masafumi Sakagami(Hyogo Medical University)Kenji Nakanishi(Hyogo Medical University)Shizuo Akira✉(Hyogo Medical University)

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Immune Response and Inflammation Inflammasome and immune disorders NF-κB Signaling PathwaysBiologySignal transducing adaptor proteinSignal transductionCell biologyReceptorInterleukin-1 receptorKinaseFunction (biology)Cancer researchImmunology

MeSH terms

AnimalsAntigens, DifferentiationCells, CulturedDNAEnzyme ActivationFemaleHumansInterleukin-1MaleMice, Inbred C57BLProteinsReceptors, ImmunologicCytokinesNF-kappa BCalcium-Calmodulin-Dependent Protein Kinases

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51

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References

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Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function · Scinovex