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Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

Cancer Letters · 2020 · Vol. 483 · pp. 127–136
Yanwei SuBin ZhaoLiangfu ZhouZheyuan ZhangYing ShenHuanhuan LvLuban Hamdy Hameed AlQudsyPeng Shang
Ferroptosis and cancer prognosisCancer, Lipids, and MetabolismDrug Transport and Resistance MechanismsGPX4Lipid peroxidationCancer cellPharmacologyCancerProgrammed cell deathSilibininChemistryCancer researchOxidative stress

MeSH terms

FerroptosisPhospholipid Hydroperoxide Glutathione PeroxidaseAnimalsAntineoplastic AgentsHumansNeoplasmsLipid PeroxidationSignal TransductionReactive Oxygen SpeciesOxidative StressTumor Microenvironment

Funding

  • National Natural Science Foundation of China
  • Northwestern Polytechnical University
  • Natural Science Foundation of Shaanxi Province
  • Science and Technology Planning Project of Shenzhen Municipality
Citations
562
FWCI
39.37
field-weighted impact
References
105
Percentile
100%
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Citations per year
References
Glutaminolysis and Transferrin Regulate Ferroptosis
Molecular Cell · 2015 · 1,981 citations
Sorafenib in Advanced Hepatocellular Carcinoma
New England Journal of Medicine · 2008 · 12,835 citations
Cellular processing of platinum anticancer drugs
Nature Reviews Drug Discovery · 2005 · 3,720 citations
Toward clinical application of the Keap1–Nrf2 pathway
Trends in Pharmacological Sciences · 2013 · 658 citations
Regulation of iron transport and the role of transferrin
Biochimica et Biophysica Acta (BBA) - General Subjects · 2011 · 511 citations
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