article Open AccessTop 1% cited
Sorafenib in Advanced Hepatocellular Carcinoma
New England Journal of Medicine · 2008 · Vol. 359(4) · pp. 378–390
Josep M. Llovet✉(Universitat de Barcelona)Sergio Ricci(University of Pisa)Vincenzo Mazzaferro(Fondazione IRCCS Istituto Nazionale dei Tumori)Philip Hilgard(University of Duisburg-Essen)Edward Gane(Auckland City Hospital)Jean Frédéric Blanc(Hôpital Saint-André)André Cosme de Oliveira(Universidade de São Paulo)Armando Santoro(Fondazione Humanitas per la Ricerca)Jean‐Luc Raoul(EU Business School, Geneva)Alejandro Forner(Centro de Investigación Biomédica en Red)Myron Schwartz(Icahn School of Medicine at Mount Sinai)Camillo Porta(Policlinico San Matteo Fondazione)Stefan Zeuzem(Goethe University Frankfurt)Luigi Bolondi(University of Bologna)Tim F. Greten(Medizinische Hochschule Hannover)Peter R. Galle(Johannes Gutenberg University Mainz)Jean François Seitz(Aix-Marseille Université)Ivan Borbath(UCLouvain)Dieter Häussinger(Heinrich Heine University Düsseldorf)Tom GiannarisMinghua Shan(Bayer (United States))M. MoscoviciD. VoliotisJordi Bruix(Universitat de Barcelona)
Abstract
In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo. (ClinicalTrials.gov number, NCT00105443.)
Hepatocellular Carcinoma Treatment and PrognosisLiver physiology and pathologyCancer Mechanisms and TherapySorafenibHepatocellular carcinomaMedicineInternal medicineVascular endothelial growth factorCarcinomaVEGF receptorsOncologyCancer research
MeSH terms
SorafenibAgedBenzenesulfonatesDouble-Blind MethodFemaleCarcinoma, HepatocellularHumansLiver NeoplasmsMaleMiddle AgedNeoplasm StagingNiacinamidePhenylurea CompoundsPyridinesProportional Hazards Models
Funding
- Falk Foundation
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Exelixis
- Bayer HealthCare
- Eisai
- Merz Pharmaceuticals
- Ipsen
Citations
12,835
FWCI
240.21
field-weighted impact
References
67
Percentile
100%
vs. same field & year
Citations per year
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References
Sorafenib in Advanced Hepatocellular Carcinoma
New England Journal of Medicine · 2008 · 12,835 citations
Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
Hepatology · 2003 · 3,004 citations
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
The Lancet Oncology · 2008 · 5,801 citations
Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma
European Journal of Cancer · 2011 · 570 citations
Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference
Journal of Hepatology · 2001 · 4,075 citations
Global Cancer Statistics, 2002
CA A Cancer Journal for Clinicians · 2005 · 18,373 citations
A Multiple Testing Procedure for Clinical Trials
Biometrics · 1979 · 3,326 citations
Transection of the oesophagus for bleeding oesophageal varices
British journal of surgery · 1973 · 7,910 citations
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