reviewTop 1% cited
Toward clinical application of the Keap1–Nrf2 pathway
Trends in Pharmacological Sciences · 2013 · Vol. 34(6) · pp. 340–346
Takafumi Suzuki(Tohoku University)Hozumi Motohashi(Tohoku University)Masayuki Yamamoto✉(Tohoku University)
Genomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsFamily Support in IllnessKEAP1Oxidative stressCarcinogenesisEnzymeDetoxification (alternative medicine)BiologyCancerPharmacologyCancer researchBioinformatics
MeSH terms
Kelch-Like ECH-Associated Protein 1AnimalsAntineoplastic AgentsCell Transformation, NeoplasticHumansOxidative StressIntracellular Signaling Peptides and ProteinsNF-E2-Related Factor 2
Funding
- Naito Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Tohoku University
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology
Citations
658
FWCI
26.31
field-weighted impact
References
61
Percentile
100%
vs. same field & year
Citations per year
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References
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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Biochemical and Biophysical Research Communications · 1997 · 3,915 citations
Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Cancer Cell · 2012 · 1,350 citations
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Nature Cell Biology · 2010 · 2,361 citations
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Genes & Development · 1999 · 3,543 citations
Nrf2: friend or foe for chemoprevention?
Carcinogenesis · 2009 · 488 citations
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
Molecular and Cellular Biology · 2003 · 1,425 citations
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
Molecular and Cellular Biology · 2004 · 2,165 citations
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