article Open AccessTop 10% cited
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
Cancer Cell · 2003 · Vol. 3(3) · pp. 285–296
Sonam Dolma✉(Whitehead Institute for Biomedical Research)Stephen L. Lessnick(Boston Children's Hospital)William C. Hahn(Dana-Farber Cancer Institute)Brent R. Stockwell(Whitehead Institute for Biomedical Research)
Cancer therapeutics and mechanismsCancer-related Molecular PathwaysLung Cancer Research StudiesCamptothecinMitoxantroneTopoisomeraseTopoisomerase inhibitorBiologySynthetic lethalityDoxorubicinCell cultureHigh-throughput screeningGenotype
MeSH terms
Antineoplastic AgentsCell LineCell Transformation, ViralDrug Screening Assays, AntitumorFibroblastsFluoresceinsFluorescent DyesGenetic EngineeringGenotypeHumansPiperazinesRetroviridaeTumor Cells, CulturedMolecular StructureOncogene Proteins
Funding
- Burroughs Wellcome Fund
- Doris Duke Charitable Foundation
- National Institutes of Health
Citations
1,396
FWCI
4.10
field-weighted impact
References
71
Percentile
95%
vs. same field & year
Citations per year
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References
Chemical genetics resulting from a passion for synthetic organic chemistry
Bioorganic & Medicinal Chemistry · 1998 · 407 citations
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
Nature Medicine · 1996 · 3,643 citations
A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay
Journal of Immunological Methods · 1994 · 1,354 citations
The causal relation between human papillomavirus and cervical cancer
Journal of Clinical Pathology · 2002 · 3,559 citations
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