article Open AccessTop 1% cited
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Nature Immunology · 2011 · Vol. 12(5) · pp. 408–415
Haitao Wen✉(University of North Carolina at Chapel Hill)Denis Gris(University of North Carolina at Chapel Hill)Yu L. Lei(University of North Carolina at Chapel Hill)Sushmita Jha(University of North Carolina at Chapel Hill)Lu Zhang(University of North Carolina at Chapel Hill)Max T. Huang(University of North Carolina at Chapel Hill)W. June Brickey(University of North Carolina at Chapel Hill)Jenny P.‐Y. Ting(University of North Carolina at Chapel Hill)
Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic DiseasesAutophagy in Disease and TherapyInflammasomeInsulin resistanceInflammationAutophagyInsulin receptorInsulinSignal transductionBiologyEndocrinologyKinase
MeSH terms
NLR Family, Pyrin Domain-Containing 3 ProteinAminoimidazole CarboxamideAnimalsAutophagyCarrier ProteinsDietary FatsEnzyme ActivationEnzyme InhibitorsFlow CytometryInsulin ResistanceMacrophagesMaleMice, Inbred C57BLOligopeptidesRibonucleotides
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1,739
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References
52
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References
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Nature Reviews Drug Discovery · 2008 · 1,751 citations
Inflammation and metabolic disorders
Nature · 2006 · 8,779 citations
Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
Cell Metabolism · 2010 · 1,246 citations
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Nature Immunology · 2009 · 2,599 citations
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Nature Immunology · 2010 · 1,297 citations
Interleukin-1β-Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression
Endocrinology · 2006 · 672 citations
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Nature Immunology · 2010 · 2,930 citations
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