review Open AccessTop 1% cited

Inflammasomes: mechanism of action, role in disease, and therapeutics

Nature Medicine · 2015 · Vol. 21(7) · pp. 677–687

Haitao Guo(University of North Carolina at Chapel Hill)Justin Callaway(University of North Carolina at Chapel Hill)Jenny P.-Y. Ting✉(University of North Carolina at Chapel Hill)

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Inflammasome and immune disorders Diabetes and associated disorders Adipokines, Inflammation, and Metabolic DiseasesInflammasomeInnate immune systemInflammationMechanism (biology)Immune systemBiologyReceptorCaspase 1DiseaseImmunology

MeSH terms

AnimalsDiseaseDisease Models, AnimalHumansInflammationModels, ImmunologicalInflammasomesMolecular Targeted Therapy

Funding

National Multiple Sclerosis Society
National Institutes of Health

Citations

3,158

FWCI

110.27

field-weighted impact

References

147

Percentile

100%

vs. same field & year

Citations per year

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References

The Inflammasome

Molecular Cell · 2002 · 5,936 citations

Obesity is associated with macrophage accumulation in adipose tissue

Journal of Clinical Investigation · 2003 · 8,580 citations

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

Nature Reviews Molecular Cell Biology · 2008 · 2,250 citations

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Nature Immunology · 2009 · 2,599 citations

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Nature Immunology · 2010 · 1,297 citations

Pattern Recognition Receptors and Inflammation

Cell · 2010 · 8,539 citations

Sterile inflammation: sensing and reacting to damage

Nature reviews. Immunology · 2010 · 2,919 citations

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Nature Immunology · 2011 · 1,739 citations

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