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Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Nucleic Acids Research · 2016 · Vol. 44(W1) · pp. W90–W97
Maxim V. KuleshovMatthew R. JonesAndrew D. RouillardNicolas FernandezQiaonan DuanZichen WangSimon KoplevSherry L. JenkinsKathleen M. JagodnikAlexander LachmannMichael G. McDermottCaroline D. MonteiroGregory W. GundersenAvi Ma’ayan

Abstract

Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams. Overall, Enrichr is a comprehensive resource for curated gene sets and a search engine that accumulates biological knowledge for further biological discoveries. Enrichr is freely available at: http://amp.pharm.mssm.edu/Enrichr.

Bioinformatics and Genomic NetworksGene expression and cancer classificationCRISPR and Genetic EngineeringUploadBiologySet (abstract data type)Web serverInterface (matter)VisualizationComputational biologyGeneApplication programming interfaceGenome

MeSH terms

HumansUser-Computer InterfaceGene LibraryGenome, HumanComputational BiologyBenchmarkingInternetGene Expression ProfilingDatabases, GeneticMolecular Sequence AnnotationGene Ontology

Funding

  • National Institutes of Health
Citations
11,349
FWCI
253.61
field-weighted impact
References
47
Percentile
100%
vs. same field & year
Citations per year
References
GREAT improves functional interpretation of cis-regulatory regions
Nature Biotechnology · 2010 · 4,934 citations
Molecular signatures database (MSigDB) 3.0
Bioinformatics · 2011 · 7,557 citations
Gene Ontology: tool for the unification of biology
Nature Genetics · 2000 · 43,975 citations
NCBI GEO: archive for functional genomics data sets—update
Nucleic Acids Research · 2012 · 10,559 citations
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Proceedings of the National Academy of Sciences · 2005 · 55,472 citations
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