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Sex-Specific Features of Microglia from Adult Mice
Cell Reports · 2018 · Vol. 23(12) · pp. 3501–3511
Alessandro Villa(University of Milan)Paolo Gelosa(Centro Cardiologico Monzino)Laura Castiglioni(University of Milan)Mauro Cimino(University of Urbino)Nicoletta Rizzi(University of Milan)Giovanna Pepe(University of Milan)Federica Lolli(University of Milan)Elena Marcello(University of Milan)Luigi Sironi(University of Milan)Elisabetta Vegeto(University of Milan)Adriana Maggi✉(University of Milan)
Abstract
Villa et al. find significant differences in the transcriptomes of microglia isolated from the brains of healthy adult male and female mice. They find that microglia from female mice are neuroprotective and that they retain this functional ability when transferred into the brains of male mice.
Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancerImmune Response and InflammationMicrogliaNeuroinflammationNeuroprotectionTranscriptomeSex characteristicsSexual differentiationHormoneSexual dimorphismNeuroscienceBiology
Funding
- European Commission
Citations
619
FWCI
27.39
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51
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100%
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References
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Neuron · 2014 · 1,980 citations
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