review Open Access

BCL-2 family members and the mitochondria in apoptosis

Genes & Development · 1999 · Vol. 13(15) · pp. 1899–1911

Atan Gross✉(Harvard University)James M. McDonnell(Rockefeller University)S J Korsmeyer(Harvard University)

Cell death mechanisms and regulation Phagocytosis and Immune Regulation Cardiac Ischemia and ReperfusionBiologyMitochondrionBcl-2 familyApoptosisCell biologyGeneticsProgrammed cell death

MeSH terms

Amino Acid SequenceAnimalsHumansMitochondriaModels, BiologicalMolecular Sequence DataProtein ConformationProtein Processing, Post-TranslationalApoptosisProto-Oncogene Proteins c-bcl-2Caspases

Citations

3,645

FWCI

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field-weighted impact

References

128

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vs. same field & year

Citations per year

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References

Two CD95 (APO-1/Fas) signaling pathways

The EMBO Journal · 1998 · 2,997 citations

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Cell · 1997 · 4,983 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

The EMBO Journal · 1997 · 1,191 citations

Bcl-2 family proteins

Oncogene · 1998 · 1,055 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

Cell · 1998 · 4,423 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

The EMBO Journal · 1998 · 1,231 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

Cell · 1997 · 5,689 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

Proteins Structure Function and Bioinformatics · 1991 · 5,244 citations

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