review Open AccessTop 1% cited
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
Cell Death and Differentiation · 2002 · Vol. 9(5) · pp. 505–512
Hamsa Puthalakath✉(Walter and Eliza Hall Institute of Medical Research)Andreas Strasser(Walter and Eliza Hall Institute of Medical Research)
Cell death mechanisms and regulationCancer-related Molecular PathwaysBioactive Compounds and Antitumor AgentsPumaCell biologyBiologyBcl-2 familyProgrammed cell deathApoptosisCaenorhabditis elegansTranscription factorGeneGenetics
MeSH terms
AnimalsCell SurvivalHumansMembrane ProteinsProtein Processing, Post-TranslationalProto-Oncogene ProteinsTranscription, GeneticApoptosisSequence Homology, Amino AcidProto-Oncogene Proteins c-bcl-2bcl-2 Homologous Antagonist-Killer Proteinbcl-2-Associated X Protein
Funding
- Leukemia and Lymphoma Society
- Dr. Josef Steiner Krebsstiftung
- National Institutes of Health
- National Health and Medical Research Council
Citations
698
FWCI
23.06
field-weighted impact
References
72
Percentile
100%
vs. same field & year
Citations per year
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References
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Molecular Cell · 2001 · 2,283 citations
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
Current Biology · 2000 · 965 citations
The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues
Molecular Cell · 2000 · 1,468 citations
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Cell · 1998 · 4,423 citations
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Cell · 1997 · 5,689 citations
PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
Molecular Cell · 2001 · 1,277 citations
Mitochondria and Apoptosis
Science · 1998 · 8,971 citations
BCL-2 family members and the mitochondria in apoptosis
Genes & Development · 1999 · 3,645 citations
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