article Open AccessTop 1% cited
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
Molecular Cell · 2012 · Vol. 49(2) · pp. 359–367
Gregory Hannum(University of California, San Diego)Justin Guinney(Sage Bionetworks)Ling Zhao(Sichuan University)Li Zhang(University of California, San Diego)Guy Hughes(University of California, San Diego)SriniVas R. Sadda(University of Southern California)Brandy Klotzle(Illumina (United States))Marina Bibikova(Illumina (United States))Jian-Bing Fan(Illumina (United States))Yuan Gao(Johns Hopkins University)Rob Deconde(University of California, San Diego)Menzies Chen(University of California, San Diego)Indika Rajapakse(Fred Hutch Cancer Center)Stephen Friend(Sage Bionetworks)Trey Ideker✉(University of California, San Diego)Kang Zhang✉(University of California, San Diego)
Epigenetics and DNA MethylationBirth, Development, and HealthRNA modifications and cancerBiologyDNA methylationGenomeComputational biologyMethylationGeneticsHuman genomeEvolutionary biologyGeneGene expression
MeSH terms
AdultAgedAged, 80 and overAgingFemaleHumansMaleMiddle AgedModels, GeneticPhenotypeGenome, HumanSequence Analysis, DNADNA MethylationEpigenesis, GeneticGenome-Wide Association Study
Funding
- Burroughs Wellcome Fund
- King Abdulaziz City for Science and Technology
- University of California, San Diego
- National Key Research and Development Program of China
Citations
4,325
FWCI
29.67
field-weighted impact
References
62
Percentile
100%
vs. same field & year
Citations per year
Cited by
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
eLife · 2020 · 616 citations
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
Bioinformatics · 2014 · 4,743 citations
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
Genome biology · 2014 · 1,158 citations
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
Nature Reviews Genetics · 2018 · 3,086 citations
Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
Cell stem cell · 2013 · 755 citations
DNA methylation aging clocks: challenges and recommendations
Genome biology · 2019 · 1,065 citations
DunedinPACE, a DNA methylation biomarker of the pace of aging
eLife · 2022 · 861 citations
DNA methylation age of human tissues and cell types
Genome biology · 2013 · 7,042 citations
References
Cancer-epigenetics comes of age
Nature Genetics · 1999 · 2,354 citations
Epigenetics and aging: the targets and the marks
Trends in Genetics · 2007 · 687 citations
High density DNA methylation array with single CpG site resolution
Genomics · 2011 · 1,761 citations
<i>The Mathematical Theory of Communication</i>
Physics Today · 1950 · 9,849 citations
A Simple Test for Heteroscedasticity and Random Coefficient Variation
Econometrica · 1979 · 5,248 citations
Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context
PLoS Genetics · 2009 · 1,085 citations
Missing value estimation methods for DNA microarrays
Bioinformatics · 2001 · 4,180 citations
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Journal of the Royal Statistical Society Series B (Statistical Methodology) · 1995 · 106,483 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
