article Open AccessTop 1% cited
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
Genome biology · 2014 · Vol. 15(2) · pp. R31–R31
Andrew E. Jaffe✉(Johns Hopkins University)Rafael A. Irizarry(Dana-Farber Cancer Institute)
Abstract
Our findings underscore the importance of considering cell composition variability in epigenetic studies based on whole blood and other heterogeneous tissue sources. We also provide software for estimating and exploring this composition confounding for the Illumina 450k microarray.
Epigenetics and DNA MethylationRNA modifications and cancerGenetic Syndromes and ImprintingEpigenomeBiologyHuman geneticsComputational biologyAssociation (psychology)Evolutionary biologyGeneticsGenome-wide association studyGenome BiologyGenomics
MeSH terms
AgingDNAHumansCpG IslandsDNA MethylationPolymorphism, Single NucleotideEpigenesis, GeneticGenome-Wide Association Study
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