article Open AccessTop 1% cited
DunedinPACE, a DNA methylation biomarker of the pace of aging
eLife · 2022 · Vol. 11
Daniel W Belsky✉(Columbia University)Avshalom Caspi(Duke University)David L Corcoran(Duke University)Karen Sugden(Duke University)Richie Poulton(University of Otago)Louise Arseneault(King's College London)Andrea Baccarelli(Columbia University)Kartik Chamarti(Duke University)Xu Gao(Peking University)Eilis Hannon(University of Exeter)Hona Lee Harrington(Duke University)Renate Houts(Duke University)Meeraj Kothari(Butler University)Dayoon Kwon(Butler University)Jonathan Mill(University of Exeter)Joel Schwartz(Harvard University)Pantel Vokonas(VA Boston Healthcare System)Cuicui Wang(Harvard University)Benjamin S Williams(Duke University)Terrie E Moffitt(Duke University)
Abstract
This research was supported by US-National Institute on Aging grants AG032282, AG061378, AG066887, and UK Medical Research Council grant MR/P005918/1.
Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model OrganismsFrailty in Older AdultsDNA methylationBiomarkerEpigeneticsPaceMedical researchDNASenescenceMethylation
MeSH terms
EpigenomeAdolescentAgingChildChild, PreschoolFemaleHumansMaleNew ZealandCohort StudiesBiomarkersDNA MethylationEpigenesis, Genetic
Funding
- Medical Research Council
- Economic and Social Research Council
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DNA methylation-based biomarkers and the epigenetic clock theory of ageing
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