reviewTop 1% cited

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

Nature Reviews Genetics · 2018 · Vol. 19(6) · pp. 371–384

Steve Horvath✉Kenneth Raj(Public Health England)

Epigenetics and DNA Methylation Birth, Development, and Health Genetics, Aging, and Longevity in Model OrganismsEpigeneticsBiologyAgeingDNA methylationComputational biologyEpigenesisEvolutionary biologyLife spanBiological ageBiomarker

MeSH terms

AgingAnimalsHumansDNA MethylationEpigenesis, Genetic

Funding

National Institute on Aging

Citations

3,086

FWCI

89.46

field-weighted impact

References

157

Percentile

100%

vs. same field & year

Citations per year

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References

Cellular senescence: when bad things happen to good cells

Nature Reviews Molecular Cell Biology · 2007 · 4,259 citations

DNA methylation age of human tissues and cell types

Genome biology · 2013 · 7,042 citations

DNA methylation: roles in mammalian development

Nature Reviews Genetics · 2013 · 3,066 citations

Epigenetics and aging: the targets and the marks

Trends in Genetics · 2007 · 687 citations

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Nucleic Acids Research · 2002 · 13,655 citations

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

PLoS Genetics · 2009 · 1,085 citations

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

Molecular Cell · 2012 · 4,325 citations

Regularization and Variable Selection Via the Elastic Net

Journal of the Royal Statistical Society Series B (Statistical Methodology) · 2005 · 20,431 citations

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