review Open AccessTop 1% cited

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

Nature Reviews Drug Discovery · 2008 · Vol. 7(6) · pp. 489–503

Masato Furuhashi✉(Harvard University)Gökhan S. Hotamışlıgil(Harvard University)

Peroxisome Proliferator-Activated Receptors Immune Response and Inflammation Metabolomics and Mass Spectrometry StudiesFatty acid-binding proteinLipid metabolismFunction (biology)Lipid signalingBiologyDrug discoveryIntracellularCell biologySignal transductionBiochemistry

MeSH terms

AnimalsBinding SitesHumansLigandsMetabolic DiseasesModels, MolecularOrgan SpecificityLipid MetabolismFatty Acid-Binding Proteins

Funding

National Institutes of Health
Japan Society for the Promotion of Science

Citations

1,751

FWCI

20.41

field-weighted impact

References

106

Percentile

100%

vs. same field & year

Citations per year

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References

Inflammation and metabolic disorders

Nature · 2006 · 8,779 citations

Obesity is associated with macrophage accumulation in adipose tissue

Journal of Clinical Investigation · 2003 · 8,580 citations

Fatty acid-binding proteins as plasma markers of tissue injury

Clinica Chimica Acta · 2004 · 484 citations

Adipocyte Fatty Acid–Binding Protein Is a Plasma Biomarker Closely Associated with Obesity and Metabolic Syndrome

Clinical Chemistry · 2006 · 602 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Journal of Clinical Investigation · 2003 · 5,825 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Journal of Clinical Investigation · 2003 · 5,644 citations

Obesity is associated with macrophage accumulation in adipose tissue

Journal of Clinical Investigation · 2003 · 8,225 citations

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