article Open AccessTop 1% cited
Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
Cell Metabolism · 2010 · Vol. 11(6) · pp. 467–478
Ling Yang(Harvard University)Ping Li(Harvard University)Suneng Fu(Harvard University)Ediz S. Calay(Harvard University)Gökhan S. Hotamışlıgil✉(Harvard University)
Autophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseasePancreatic function and diabetesAutophagyATG5Downregulation and upregulationInsulin resistanceInsulinBiologyEndocrinologyInternal medicineCell biologyInsulin receptor
MeSH terms
Autophagy-Related Protein 5Autophagy-Related Protein 7AnimalsAutophagyEndoplasmic ReticulumInsulin ResistanceLiverMice, ObeseMicrotubule-Associated ProteinsObesitySignal TransductionMice
Funding
- University of Tokyo
- Tokyo Medical and Dental University
- National Institutes of Health
- Health Sciences Center, University of New Mexico
- School of Medicine, University of New Mexico
Citations
1,246
FWCI
35.11
field-weighted impact
References
38
Percentile
100%
vs. same field & year
Citations per year
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References
ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
Cell Death and Differentiation · 2006 · 912 citations
Autophagosome formation: core machinery and adaptations
Nature Cell Biology · 2007 · 2,136 citations
Inflammation and metabolic disorders
Nature · 2006 · 8,779 citations
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
Cell Metabolism · 2007 · 1,898 citations
Autophagy: molecular machinery for self-eating
Cell Death and Differentiation · 2005 · 1,525 citations
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
Nature Cell Biology · 2006 · 1,272 citations
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy
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Autophagy in the Pathogenesis of Disease
Cell · 2008 · 6,967 citations
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