reviewTop 1% cited
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Nature Reviews Drug Discovery · 2014 · Vol. 13(9) · pp. 673–691
Katrina J. Falkenberg✉(Peter MacCallum Cancer Centre)Ricky W. Johnstone(Peter MacCallum Cancer Centre)
Histone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsEpigenetics and DNA MethylationEpigeneticsHistoneBiologyEpigenesisHistone deacetylaseCancerImmune systemCancer epigeneticsBioinformaticsGene expression
MeSH terms
AnimalsHistone DeacetylasesHumansImmune System DiseasesNeoplasmsNervous System DiseasesEpigenesis, GeneticHistone Deacetylase Inhibitors
Citations
1,501
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69.33
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References
282
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References
Anticancer activities of histone deacetylase inhibitors
Nature Reviews Drug Discovery · 2006 · 2,905 citations
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Nature Genetics · 2003 · 6,253 citations
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
Nature Reviews Drug Discovery · 2002 · 1,513 citations
A decade of exploring the cancer epigenome — biological and translational implications
Nature reviews. Cancer · 2011 · 2,835 citations
Chromatin Modifications and Their Function
Cell · 2007 · 10,677 citations
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
Nature reviews. Cancer · 2006 · 2,190 citations
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas
Leukemia · 2008 · 439 citations
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
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