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Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

Nature Reviews Drug Discovery · 2002 · Vol. 1(4) · pp. 287–299
Ricky W. Johnstone
Histone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysHistone deacetylaseHistone AcetyltransferasesHistoneHistone deacetylase 5Cancer researchHDAC11ChromatinChromatin remodelingBiologyHDAC10

MeSH terms

AcetylationAnimalsAntineoplastic AgentsCell DifferentiationChromatinClinical Trials as TopicEnzyme InhibitorsHistonesHumansNeoplasmsGene Expression Regulation, NeoplasticApoptosisDNA MethylationHistone Deacetylase Inhibitors

Funding

  • Wellcome Trust
  • National Health and Medical Research Council
  • National Medical Research Council
Citations
1,513
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