article Open AccessTop 1% cited
The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo
PLoS Pathogens · 2015 · Vol. 11(9) · pp. e1005142–e1005142
Ole S. Søgaard✉(Aarhus University Hospital)Mette E. Graversen(Aarhus University Hospital)Steffen Leth(Aarhus University Hospital)Rikke Olesen(Aarhus University Hospital)Christel R. Brinkmann(Aarhus University Hospital)Sara Konstantin Nissen(Aarhus University Hospital)Andreas Kjær(Aarhus University)Mariane Høgsbjerg Schleimann(Aarhus University)Paul W. Denton(Aarhus University)William J. Hey-Cunningham(UNSW Sydney)Kersten K. Koelsch(UNSW Sydney)Giuseppe Pantaleo(University of Lausanne)Kim Krogsgaard(Bionor (Norway))Maja A. Sommerfelt(Bionor (Norway))Rémi Fromentin(Centre Hospitalier de l’Université de Montréal)Nicolas Chomont(Université du Québec à Montréal)Thomas A. Rasmussen(Aarhus University Hospital)Lars Østergaard(Aarhus University Hospital)Martin Tolstrup(Aarhus University)
Abstract
clinicaltrials.gov NTC02092116.
HIV Research and TreatmentHIV/AIDS drug development and treatmentHIV/AIDS Research and InterventionsRomidepsinDepsipeptideIn vivoHuman immunodeficiency virus (HIV)ChemistryBiologyVirologyGeneticsHistone deacetylaseStereochemistry
MeSH terms
AcetylationAdultDrug InteractionsFemaleFollow-Up StudiesHistonesHumansInfusions, IntravenousLymphocytesMaleMiddle AgedProtein Processing, Post-TranslationalRNA, ViralVirus ActivationCohort Studies
Funding
- Celgene
- Norges Forskningsråd
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
Citations
519
FWCI
29.51
field-weighted impact
References
52
Percentile
100%
vs. same field & year
Citations per year
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References
Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy
PLoS Pathogens · 2014 · 509 citations
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Nature Reviews Drug Discovery · 2014 · 1,501 citations
New Real-Time Reverse Transcriptase-Initiated PCR Assay with Single-Copy Sensitivity for Human Immunodeficiency Virus Type 1 RNA in Plasma
Journal of Clinical Microbiology · 2003 · 609 citations
ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
Journal of Immunological Methods · 2009 · 2,135 citations
Emergence of Resistant Human Immunodeficiency Virus Type 1 in Patients Receiving Fusion Inhibitor (T-20) Monotherapy
Antimicrobial Agents and Chemotherapy · 2002 · 1,578 citations
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