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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

Nature Immunology · 2012 · Vol. 13(3) · pp. 255–263
Chong-Shan ShiKevin ShenderovNing-Na HuangJuraj KabátMones Abu‐AsabKatherine A. FitzgeraldAlan SherJohn H. Kehrl
Autophagy in Disease and TherapyInflammasome and immune disordersPhagocytosis and Immune RegulationAutophagyInflammasomeSignal transducing adaptor proteinAIM2Cell biologyAutophagosomeUbiquitinCaspase 1InflammationChemistry

MeSH terms

NLR Family, Pyrin Domain-Containing 3 ProteinAnimalsAutophagyCarrier ProteinsCell LineDNA-Binding ProteinsHumansInflammationNuclear ProteinsSignal Transductionral GTP-Binding ProteinsMiceInterleukin-1betaUbiquitinationInflammasomes

Funding

  • Tokyo Medical and Dental University
  • Takeda Oncology
  • National Institute of Allergy and Infectious Diseases
Citations
1,359
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