article Open AccessTop 1% cited

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Nature Immunology · 2010 · Vol. 11(5) · pp. 395–402

Vijay Rathinam✉(Office of Infectious Diseases)Zhaozhao Jiang(Office of Infectious Diseases)Stephen N. Waggoner(University of Massachusetts Chan Medical School)Shruti Sharma(Office of Infectious Diseases)Leah E. Cole(University of Maryland, Baltimore)Lisa Waggoner(Office of Infectious Diseases)Sivapriya Kailasan Vanaja(University of Massachusetts Chan Medical School)Brian G. Monks(Office of Infectious Diseases)Sandhya Ganesan(Office of Infectious Diseases)Eicke Latz(University of Bonn)Veit Hornung(University of Bonn)Stefanie N. Vogel(University of Maryland, Baltimore)Eva Szomolanyi‐Tsuda(University of Massachusetts Chan Medical School)Katherine A. Fitzgerald(Office of Infectious Diseases)

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Inflammasome and immune disorders interferon and immune responses Kawasaki Disease and Coronary ComplicationsAIM2PyroptosisInflammasomeBiologyCaspase 1Innate immune systemFrancisella tularensisMicrobiologyVirologyImmune system

MeSH terms

AnimalsCell LineCytoskeletal ProteinsDNADNA Virus InfectionsDNA VirusesDNA-Binding ProteinsFrancisella tularensisHumansImmunity, InnateKiller Cells, NaturalListeriosisLymphocyte ActivationMacrophagesMice, Inbred C57BL

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Inflammasomes: Key regulators of inflammation and emerging therapeutic targets