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Identification of ACSL4 as a biomarker and contributor of ferroptosis

Biochemical and Biophysical Research Communications · 2016 · Vol. 478(3) · pp. 1338–1343

Hua Yuan(Jilin University)Xuemei Li(Qingdao Municipal Hospital)Xiuying Zhang(Jilin University)Rui Kang(University of Pittsburgh)Daolin Tang✉(University of Pittsburgh)

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Cancer, Lipids, and Metabolism Ferroptosis and cancer prognosis RNA modifications and cancerLNCaPProgrammed cell deathGene knockdownApoptosisBiologyTransfectionCancer researchK562 cellsCell biologyCancer cell

MeSH terms

Long-Chain-Fatty-Acid-CoA LigaseCoenzyme A LigasesHumansHydroxyeicosatetraenoic AcidsPiperazinesBiomarkers, TumorApoptosisCell Line, TumorGene Knockdown Techniques

Funding

National Science Foundation
Natural Science Foundation of Jilin Province
Natural Science Foundation of Guangdong Province
National Institutes of Health
National Institutes of Natural Sciences

Citations

1,037

FWCI

10.34

field-weighted impact

References

38

Percentile

99%

vs. same field & year

Citations per year

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References

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Cell · 2012 · 17,296 citations

Regulation of Ferroptotic Cancer Cell Death by GPX4

Cell · 2014 · 7,213 citations

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Nature Cell Biology · 2014 · 3,521 citations

Fatty acid metabolism: target for metabolic syndrome

Journal of Lipid Research · 2008 · 714 citations

Hallmarks of Cancer: The Next Generation

Cell · 2011 · 65,668 citations

Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Hepatology · 2015 · 1,974 citations

Ferroptosis: process and function

Cell Death and Differentiation · 2016 · 3,675 citations

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