reviewTop 1% cited

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

Cell Death and Differentiation · 2000 · Vol. 7(12) · pp. 1166–1173

S J Korsmeyer✉(Howard Hughes Medical Institute)Michael C. Wei(Washington University in St. Louis)Mitsuyoshi Saito(Washington University in St. Louis)Solly Weiler(Dana-Farber Cancer Institute)Kyoung Joon Oh(Dana-Farber Cancer Institute)Paul H. Schlesinger(Washington University in St. Louis)

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Cell death mechanisms and regulation RNA Interference and Gene Delivery PARP inhibition in cancer therapyCytochrome cCell biologyApoptosomeChemistryApoptosisCytochromeMitochondrionProgrammed cell deathMitochondrial apoptosis-induced channelBiophysics

MeSH terms

AnimalsCarrier ProteinsCytochrome c GroupHumansMembrane ProteinsMitochondriaProto-Oncogene ProteinsSignal TransductionApoptosisProto-Oncogene Proteins c-bcl-2bcl-2 Homologous Antagonist-Killer ProteinBH3 Interacting Domain Death Agonist Proteinbcl-2-Associated X Protein

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Bcl-2 family proteins and cancer