review Open AccessTop 1% cited
The CD95(APO-1/Fas) DISC and beyond
Cell Death and Differentiation · 2003 · Vol. 10(1) · pp. 26–35
Marcus E. Peter✉(May Institute)Peter H. Krammer(German Cancer Research Center)
Cell death mechanisms and regulationPhagocytosis and Immune RegulationImmune Response and InflammationFas receptorDeath domainApoptosisCell biologySignal transducing adaptor proteinProgrammed cell deathFas ligandReceptorCaspaseSignal transduction
MeSH terms
AnimalsEukaryotic CellsHumansSignal TransductionApoptosisReceptors, Tumor Necrosis Factorfas ReceptorCaspasesMacromolecular SubstancesDeath Domain Receptor Signaling Adaptor Proteins
Funding
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Deutsche Krebshilfe
- National Institutes of Health
Citations
1,064
FWCI
27.45
field-weighted impact
References
123
Percentile
100%
vs. same field & year
Citations per year
Cited by
Natural Innate and Adaptive Immunity to Cancer
Annual Review of Immunology · 2011 · 2,024 citations
Mechanisms of natural killer cell-mediated cellular cytotoxicity
Journal of Leukocyte Biology · 2019 · 587 citations
Control of apoptosis by p53
Oncogene · 2003 · 1,397 citations
Inflammatory caspases and inflammasomes: master switches of inflammation
Cell Death and Differentiation · 2006 · 819 citations
Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response
Biochimica et Biophysica Acta (BBA) - Bioenergetics · 2006 · 690 citations
References
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
Nature Immunology · 2000 · 1,899 citations
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
The EMBO Journal · 1995 · 2,138 citations
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
Annual Review of Biochemistry · 1999 · 2,764 citations
Two CD95 (APO-1/Fas) signaling pathways
The EMBO Journal · 1998 · 2,997 citations
The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues
Molecular Cell · 2000 · 1,468 citations
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
Cell Death and Differentiation · 2000 · 1,027 citations
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
The EMBO Journal · 1997 · 1,191 citations
Apoptosis signaling by death receptors
European Journal of Biochemistry · 1998 · 970 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.