articleTop 1% cited
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Nature Immunology · 2003 · Vol. 4(4) · pp. 337–342
Roli Khattri✉Tom Cox(Celltechgen (United States))Sue-Ann Yasayko(Celltechgen (United States))Fred Ramsdell(Celltechgen (United States))
Immune Cell Function and InteractionT-cell and B-cell ImmunologyNF-κB Signaling PathwaysFOXP3IL-2 receptorBiologyCell biologyCytotoxic T cellCTLA-4Interleukin 21CD8Transcription factorT cell
MeSH terms
AbataceptAnimalsAntigens, DifferentiationDNA-Binding ProteinsMice, TransgenicReceptors, Interleukin-2CD4-Positive T-LymphocytesAntigens, CDTransforming Growth Factor betaInterleukin-10Receptors, Nerve Growth FactorReceptors, Tumor Necrosis FactorImmunoconjugatesMiceForkhead Transcription Factors
Funding
- University of Washington
Citations
2,816
FWCI
69.36
field-weighted impact
References
34
Percentile
100%
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References
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Nature Genetics · 2001 · 3,333 citations
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
Nature Immunology · 2001 · 1,632 citations
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
Nature Genetics · 2001 · 2,563 citations
CD4+CD25+ Immunoregulatory T Cells
Immunity · 2002 · 1,397 citations
Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
Nature Immunology · 2002 · 1,718 citations
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
Immunity · 1995 · 2,880 citations
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
The Journal of Experimental Medicine · 2000 · 2,205 citations
Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β
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