articleTop 10% cited
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
Nature Genetics · 2001 · Vol. 27(1) · pp. 68–73
Mary E. Brunkow✉(University of Washington Bothell)Eric W. JefferyKathryn A. HjerrildBryan PaeperLisa B. ClarkSue-Ann YasaykoJohn E. Wilkinson(Oak Ridge National Laboratory)David J. Galas(Keck Graduate Institute)Steven F. Ziegler(Virginia Mason Medical Center)Fred Ramsdell
Invertebrate Immune Response MechanismsVitamin C and Antioxidants ResearchAquaculture disease management and microbiotaBiologyForkhead Transcription FactorsFOXP3FOXA2GeneticsFrameshift mutationGeneMutationRegulatory T cellCD8
MeSH terms
Amino Acid SequenceAnimalsCloning, MolecularDNA Mutational AnalysisDNA-Binding ProteinsFemaleGenes, RecessiveGenetic Complementation TestHumansLymph NodesLymphoproliferative DisordersMaleMice, Mutant StrainsMice, TransgenicMolecular Sequence Data
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References
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Nature Genetics · 2001 · 3,333 citations
Basic local alignment search tool
Journal of Molecular Biology · 1990 · 93,570 citations
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
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Prediction of complete gene structures in human genomic DNA
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