article Open AccessTop 1% cited
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
Immunity · 1995 · Vol. 3(5) · pp. 541–547
Elizabeth Tivol✉(Brigham and Women's Hospital)Frank BorrielloAlain SchweitzerWilliam P. LynchJ A Bluestone(University of Chicago)Arlene H. Sharpe
T-cell and B-cell ImmunologyImmune Cell Function and InteractionDiabetes and associated disordersCTLA-4CD28BiologyT cellImmunologyCytotoxic T cellCell biologyImmune systemIn vitroGenetics
MeSH terms
AbataceptAnimalsAntigens, DifferentiationBase SequenceCells, CulturedImmunohistochemistryLymphocyte ActivationLymphoid TissueLymphoproliferative DisordersMice, Mutant StrainsMice, TransgenicMolecular Sequence DataT-LymphocytesVisceraDown-Regulation
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References
CTLA-4 can function as a negative regulator of T cell activation
Immunity · 1994 · 2,184 citations
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
The Journal of Experimental Medicine · 1995 · 2,186 citations
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