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CD4+CD25+ Immunoregulatory T Cells
Immunity · 2002 · Vol. 16(2) · pp. 311–323
Rebecca S. McHugh✉(National Institute of Allergy and Infectious Diseases)Matthew J. WhittersCiriaco A. Piccirillo(National Institute of Allergy and Infectious Diseases)Deborah YoungEthan M. Shevach(National Institute of Allergy and Infectious Diseases)Mary CollinsMichael C. Byrne
T-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune ResponsesIL-2 receptorBiologyCell biologyPhenotypeReceptorT cellEffectorPopulationMolecular biologyGene
MeSH terms
Gene ExpressionAnimalsAntibodies, MonoclonalCell SeparationFemaleGlucocorticoidsInterleukin-2Lymphocyte ActivationMice, Inbred BALB CMice, Inbred C57BLReceptors, Cell SurfaceReceptors, Interleukin-2BiomarkersCD4-Positive T-LymphocytesAntigens, CD
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N<scp>aturally</scp>A<scp>rising</scp>CD4<sup>+</sup>R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>
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References
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Nature Immunology · 2010 · 5,839 citations
B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes
Immunity · 2000 · 2,031 citations
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
The Journal of Experimental Medicine · 1998 · 2,598 citations
An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation
The Journal of Experimental Medicine · 1999 · 1,584 citations
Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific
The Journal of Immunology · 2000 · 1,225 citations
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
The Journal of Experimental Medicine · 2000 · 2,205 citations
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
The Journal of Experimental Medicine · 2000 · 2,174 citations
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
The Journal of Immunology · 1995 · 5,432 citations
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