articleTop 10% cited
Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions
Clinical Cancer Research · 2006 · Vol. 12(18) · pp. 5423–5434
Nobuyoshi Hiraoka✉(National Cancer Research Institute)Kaoru Onozato(National Cancer Research Institute)Tomoo Kosuge(Tokyo National Hospital)Setsuo Hirohashi(National Cancer Research Institute)
Abstract
T(R) play a role in controlling the immune response against pancreatic ductal carcinoma from the premalignant stage to established cancer. In pancreatic ductal carcinoma, a high prevalence of TR seems to be a marker of poor prognosis.
Immune Cell Function and InteractionCancer Immunotherapy and BiomarkersT-cell and B-cell ImmunologyPancreatic Intraepithelial NeoplasiaFOXP3MedicineImmune systemAdenocarcinomaIntraepithelial neoplasiaPancreasPathologyIntraepithelial lymphocyteCarcinogenesis
MeSH terms
AdenocarcinomaAdenocarcinoma, PapillaryAdultAgedAged, 80 and overAnimalsAntibodies, MonoclonalCarcinoma, Intraductal, NoninfiltratingAdenocarcinoma, MucinousFemaleCricetinaeHumansMaleMiddle AgedPancreatic Neoplasms
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References
CD4+CD25+ suppressor T cells: more questions than answers
Nature reviews. Immunology · 2002 · 2,106 citations
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Nature Immunology · 2010 · 5,839 citations
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
Nature Genetics · 2001 · 2,563 citations
Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>
Science · 2003 · 8,062 citations
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
Nature Immunology · 2005 · 2,654 citations
Cancer Statistics, 2005
CA A Cancer Journal for Clinicians · 2005 · 5,459 citations
An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms
The American Journal of Surgical Pathology · 2004 · 1,072 citations
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Nature Immunology · 2003 · 2,816 citations
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