article Open AccessTop 1% cited
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia
The EMBO Journal · 2003 · Vol. 22(16) · pp. 4082–4090
Edurne Berra✉(Centre Antoine Lacassagne)
Cancer, Hypoxia, and MetabolismHigh Altitude and HypoxiaMitochondrial Function and PathologyHydroxylationBiologyUbiquitin ligaseCell biologyOxygen tensionUbiquitinGene silencingHypoxia-Inducible Factor 1Downregulation and upregulationHypoxia (environmental)
MeSH terms
HypoxiaBiological TransportCell LineCell NucleusDNA-Binding ProteinsDose-Response Relationship, DrugHeLa CellsHumansHydroxylationIsoenzymesNuclear ProteinsOxygenProcollagen-Proline DioxygenaseRecombinant ProteinsRNA, Messenger
Funding
- McKnight Foundation
Citations
1,329
FWCI
23.84
field-weighted impact
References
50
Percentile
100%
vs. same field & year
Citations per year
Cited by
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
Molecular Cell · 2008 · 3,185 citations
Vitamins C and E: Beneficial effects from a mechanistic perspective
Free Radical Biology and Medicine · 2011 · 1,008 citations
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
Cell Metabolism · 2005 · 1,498 citations
Hypoxia-Inducible Factor-1 (HIF-1)
Molecular Pharmacology · 2006 · 1,635 citations
Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review
Frontiers in Pharmacology · 2011 · 424 citations
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
Molecular and Cellular Biology · 2009 · 1,440 citations
Hypoxia-inducible factors in the kidney
American Journal of Physiology-Renal Physiology · 2006 · 333 citations
References
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Nature · 2001 · 9,337 citations
High-efficiency transformation of mammalian cells by plasmid DNA.
Molecular and Cellular Biology · 1987 · 5,334 citations
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
Genes & Development · 2002 · 1,520 citations
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences · 1995 · 6,172 citations
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
Nature Cell Biology · 2000 · 1,582 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.