article Open AccessTop 1% cited

HIF-1alpha is required for solid tumor formation and embryonic vascularization

The EMBO Journal · 1998 · Vol. 17(11) · pp. 3005–3015

Heather E. Ryan✉(University of California, San Diego)

Cancer, Hypoxia, and Metabolism RNA modifications and cancer Epigenetics and DNA MethylationBiologyEmbryonic stem cellCell biologySolid tumorCancer researchMolecular biologyGeneticsCancerGene

MeSH terms

AnimalsDNA-Binding ProteinsEmbryo, MammalianGene Expression RegulationHeadMaleNervous SystemNuclear ProteinsPhosphoglycerate KinaseStem CellsTranscription FactorsYolk SacCell HypoxiaUp-RegulationApoptosis

Funding

University of California, San Diego

Citations

1,593

FWCI

22.93

field-weighted impact

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100%

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References

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

Circulation Research · 1995 · 1,035 citations

Purification and Characterization of Hypoxia-inducible Factor 1

Journal of Biological Chemistry · 1995 · 2,061 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Proceedings of the National Academy of Sciences · 1995 · 6,172 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

Molecular and Cellular Biology · 1992 · 2,445 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

Molecular and Cellular Biology · 1996 · 3,948 citations

A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation

Molecular and Cellular Biology · 1992 · 912 citations

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