articleTop 1% cited

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Nature Genetics · 2018 · Vol. 50(9) · pp. 1219–1224

Amit V. Khera✉(Broad Institute)Mark Chaffin(Broad Institute)Krishna G. Aragam(Broad Institute)Mary E. Haas(Broad Institute)Carolina Roselli(Broad Institute)Seung Hoan Choi(Broad Institute)Pradeep Natarajan(Broad Institute)Eric S. Lander(Broad Institute)Steven A. Lubitz(Broad Institute)Patrick T. Ellinor(Broad Institute)Sekar Kathiresan(Broad Institute)

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Genetic Associations and Epidemiology Genomics and Rare Diseases Genetic factors in colorectal cancerBiologyDiseaseGeneticsMultifactorial InheritancePopulationPolygenic risk scoreCoronary artery diseaseBioinformaticsInternal medicineMedicine

MeSH terms

AdultAgedDiseaseFemaleHumansMaleMiddle AgedMutationRisk FactorsGenetic Predisposition to DiseaseMultifactorial InheritancePolymorphism, Single NucleotideGenome-Wide Association Study

Funding

KR Foundation

Citations

2,994

FWCI

255.14

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100%

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References

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Nature Genetics · 2015 · 2,673 citations

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