review Open AccessTop 1% cited

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

Nature Genetics · 2015 · Vol. 47(10) · pp. 1121–1130

Alexandre F Stewart ✉(Canadian Heart Research Centre)Majid Nikpay(University of Ottawa) Ruth McPherson(Canadian Heart Research Centre) Christopher Grace(Centre for Human Genetics) Shapour Jalilzadeh(Centre for Human Genetics) Hugh Watkins (University of Oxford)Anuj Goel(Centre for Human Genetics) Martin Farrall(Centre for Human Genetics) Theodosios Kyriakou(University of Oxford) Christopher Grace(University of Oxford) Natalie R van Zuydam(University of Dundee) Shapour Jalilzadeh(Centre for Human Genetics) Hugh Watkins (University of Oxford) Cecilia M Lindgren(Massachusetts Institute of Technology) Erik Ingelsson(Uppsala University)Anuj Goel(Centre for Human Genetics) Martin Farrall(University of Oxford) Andrew P Morris(University of Oxford) Theodosios Kyriakou(University of Oxford) Richa Saxena(Broad Institute) Andrew Bjonnes(Center for Human Genetics) Tõnu Esko (Broad Institute)Hong-Hee Won(Broad Institute) Cecilia M Lindgren(University of Oxford) Sekar Kathiresan(Massachusetts Institute of Technology)Hong-Hee Won (Massachusetts Institute of Technology) Sekar Kathiresan(Center for Human Genetics)Hong-Hee Won(Center for Human Genetics) Sekar Kathiresan(Massachusetts General Hospital) Andrew Bjonnes(Broad Institute) Richa Saxena (Center for Human Genetics)Hong-Hee Won (Harvard University) Sekar Kathiresan(Massachusetts Institute of Technology) Thomas R Webb (NIHR Leicester Cardiovascular Biomedical Research Unit)Leanne M Hall(University of Leicester) Christopher P Nelson(Glenfield Hospital) Nilesh J Samani(Glenfield Hospital)Christina Willenborg (University of Lübeck) Jeanette Erdmann(Institute for Integrative and Experimental Genomics)Christina Willenborg(University of Lübeck) Jeanette Erdmann(Institute for Integrative and Experimental Genomics) Inke R König (University of Lübeck) Kathleen E Stirrups (Queen Mary University of London) Panos Deloukas(William Harvey Research Institute)Stavroula Kanoni(William Harvey Research Institute) Wei Zhao(University of Pennsylvania)Danish Saleheen (University of Pennsylvania) Maria Samuel(Center for Non-Communicable Diseases) Philippe Frossard(Center for Non-Communicable Diseases)Danish Saleheen(University of Pennsylvania) Asif Rasheed (Center for Non-Communicable Diseases) Nilesh J Samani(University of Leicester) Thomas R Webb(Glenfield Hospital) Alison H Goodall (NIHR Leicester Cardiovascular Biomedical Research Unit)Christopher P Nelson(Glenfield Hospital) King Wai Lau(University of Oxford) Rory Collins (University of Oxford) Robert Clarke(University of Oxford)Jemma C Hopewell(University of Oxford)Lingyao Zeng(Deutsches Herzzentrum München) Thorsten Kessler(Klinikum rechts der Isar) Heribert Schunkert(Technical University of Munich) Christian Hengstenberg (Deutsches Herzzentrum München) Christian Hengstenberg (German Centre for Cardiovascular Research) Annette Peters(Helmholtz Zentrum München) Thomas Meitinger(German Centre for Cardiovascular Research)Lingyao Zeng(Technical University of Munich) Christian Gieger(German Centre for Cardiovascular Research) Heribert Schunkert(Deutsches Herzzentrum München)Abbas Dehghan(Erasmus MC) Albert Hofman(Erasmus MC) Andre Uitterlinden(Erasmus MC) Oscar H Franco (Erasmus MC) Paul S de Vries(Erasmus MC) Evelin Mihailov(University of Tartu) Andres Metspalu (University of Tartu) Markus Perola(Finnish Institute for Health and Welfare) Natalia Pervjakova(University of Helsinki) Tõnu Esko(University of Tartu)Maris Alver(University of Tartu) Andres Metspalu(University of Tartu)Maris Alver (University of Tartu)Sebastian M Armasu (Mayo Clinic in Florida) Mariza de Andrade(Mayo Clinic in Florida)Kirsi Auro(University of Helsinki) Natalia Pervjakova (University of Tartu) Markus Perola(University of Helsinki) Markus Perola (Finnish Institute for Health and Welfare) Emmi Tikkanen(Institute for Molecular Medicine Finland) Natalia Pervjakova(University of Tartu)Kirsi Auro(Institute for Molecular Medicine Finland) Samuli Ripatti(University of Helsinki)Kirsi Auro(Finnish Institute for Health and Welfare) Natalia Pervjakova (University of Helsinki) Markus Perola(University of Tartu) Julie E Buring (Brigham and Women's Hospital)Daniel I Chasman(Brigham and Women's Hospital) Paul M Ridker(Brigham and Women's Hospital) Lynda M Rose(Brigham and Women's Hospital)Daniel I Chasman (Harvard University) Paul M Ridker(Harvard University) Laiyuan Wang (Chinese National Human Genome Center) Xueli Yang(Chinese Academy of Medical Sciences & Peking Union Medical College) Dongfeng Gu(Chinese Academy of Medical Sciences & Peking Union Medical College) Xiangfeng Lu(Chinese Academy of Medical Sciences & Peking Union Medical College)Shufeng Chen(Chinese Academy of Medical Sciences & Peking Union Medical College)Ian Ford(University of Glasgow)Nora Franceschini(University of North Carolina at Chapel Hill)Christian Gieger (Helmholtz Zentrum München) Annette Peters(German Centre for Cardiovascular Research)Christian Gieger(Helmholtz Zentrum München) Erik Ingelsson(Stanford University)Stefan Gustafsson (Uppsala University) Erik Ingelsson(Centre for Human Genetics)Stefan Gustafsson (Science for Life Laboratory) John Danesh (University of Cambridge) Samuli Ripatti(Institute for Molecular Medicine Finland)Jie Huang(Wellcome Sanger Institute) L Adrienne Cupples (Framingham Heart Study) Christopher J O'Donnell(Framingham Heart Study)Shih-Jen Hwang(Boston University) L Adrienne Cupples(Boston University)Shih-Jen Hwang (Framingham Heart Study)Yun Kyoung Kim Bong-Jo Kim Bok-Ghee Han Winfried März(University Medical Centre Mannheim)Marcus E Kleber (University Hospital Heidelberg) Ruth J F Loos(Icahn School of Medicine at Mount Sinai) Omri Gottesman(Icahn School of Medicine at Mount Sinai) Erwin P Bottinger (Icahn School of Medicine at Mount Sinai)Yingchang Lu(Icahn School of Medicine at Mount Sinai) Ruth J F Loos(Icahn School of Medicine at Mount Sinai)Yingchang Lu (Icahn School of Medicine at Mount Sinai)Leo-Pekka Lyytikäinen(Tampere University) Pekka J Karhunen (Tampere University) Terho Lehtimäki(Tampere University) Terho Lehtimäki(Tampere University)Leo-Pekka Lyytikäinen (Tampere University)Alanna C Morrison (The University of Texas Health Science Center at Houston) Eric Boerwinkle(The University of Texas Health Science Center at Houston)Liming Qu(University of Pennsylvania) Thomas Quertermous (Stanford University) Erik Ingelsson(Science for Life Laboratory) Themistocles L Assimes(Cardiovascular Institute of the South)Elias Salfati(Stanford University)Richa Saxena(Center for Human Genetics)Markus Scholz(Leipzig University) Frank Beutner (Leipzig Heart Institute) Joachim Thiery(University Hospital Leipzig)Markus Scholz(Leipzig University)Albert V Smith (University of Iceland) Vilmundur Gudnason(University of Iceland)Albert V Smith (Icelandic Heart Association) Vilmundur Gudnason(University of Iceland) Samuli Ripatti(Institute for Molecular Medicine Finland)Emmi Tikkanen (Institute for Molecular Medicine Finland)Weihua Zhang (Imperial College London) John C Chambers(Imperial College London) John C Chambers (Imperial College Healthcare NHS Trust) Jaspal S Kooner(Ealing Hospital)Weihua Zhang(Ealing Hospital) Colin N Palmer(University of Dundee)Natalie R van Zuydam (University of Oxford)Sonia S Anand(Population Health Research Institute)Lars Bertram(Imperial College London)Lars Bertram(Institute for Integrative and Experimental Genomics)Frank Beutner(Leipzig Heart Institute)George Dedoussis(Harokopio University of Athens)Dominique Gauguier(Inserm)Alison H Goodall(Glenfield Hospital) Pierre A Zalloua(Harvard University)Marc Haber (Lebanese American University)Jianfeng Huang(Wellcome Sanger Institute)Thorsten Kessler(Technical University of Munich)Inke R König(University of Lübeck)Lars Lannfelt(Uppsala University)Wolfgang Lieb(Christian-Albrechts-Universität zu Kiel)Lars Lind(Uppsala University)Marja-Liisa Lokki(University of Helsinki) Nancy L Pedersen(Karolinska Institutet)Patrik K Magnusson (Karolinska Institutet)Nadeem H Mallick(Punjab Institute of Cardiology)Narinder Mehra(All India Institute of Medical Sciences)Thomas Meitinger(Helmholtz Zentrum München)Thomas Meitinger(Helmholtz Zentrum München) Asif Rasheed(Center for Non-Communicable Diseases)Fazal-ur-Rehman Memon Andrew P Morris(University of Oxford)Markku S Nieminen Juha SinisaloLoukianos S Rallidis(University General Hospital Attikon) Christopher B Granger(Duke Medical Center)Svati H Shah (Duke Medical Center)Kathleen E Stirrups(University of Cambridge) J Wouter Jukema(Leiden University Medical Center)Stella Trompet (Leiden University Medical Center)Stella Trompet(Leiden University Medical Center)Laiyuan Wang(Chinese Academy of Medical Sciences & Peking Union Medical College)Khan S ZamanDiego Ardissino(Ospedale di Parma)Diego Ardissino(Ospedale di Parma)Eric Boerwinkle(The University of Texas Health Science Center at Houston) Mary F Feitosa(Washington University in St. Louis)Ingrid B Borecki (Washington University in St. Louis)John C Chambers (Imperial College Healthcare NHS Trust) Jaspal S Kooner(Imperial College London)John Danesh(Wellcome Sanger Institute)Ilja Demuth(Charité - Universitätsmedizin Berlin)Ilja Demuth(Charité - Universitätsmedizin Berlin)Ilja Demuth(Charité - Universitätsmedizin Berlin)Roberto Elosua(Hospital del Mar Research Institute)Stephen E Epstein(MedStar Heart & Vascular Institute)Tõnu Esko(Massachusetts Institute of Technology)Tõnu Esko(Broad Institute)Maria Grazia FranzosiAlistair S Hall(University of Leeds)Anders Hamsten(Karolinska Institutet)Tamara B Harris(National Institute on Aging)Stanley L Hazen(Cleveland Clinic)Carlos Iribarren(Kaiser Permanente)J Wouter Jukema(Netherlands Heart Institute)J Wouter Jukema(Netherlands Heart Institute)Pekka J Karhunen(Tampere University of Applied Sciences)Jaspal S Kooner(Imperial College London)Iftikhar J Kullo(Mayo Clinic)Ruth J F Loos(Icahn School of Medicine at Mount Sinai)Olle MelanderWinfried März(Heidelberg University)Winfried März(Medical University of Graz)Thomas Quertermous (Stanford University) Themistocles L Assimes(Stanford University)Daniel J Rader(Cardiovascular Institute of the South)Daniel J Rader (University of Pennsylvania) Muredach P Reilly(University of Pennsylvania)Robert Roberts(University of Ottawa)Veikko Salomaa(Finnish Institute for Health and Welfare)Dharambir K Sanghera(University of Oklahoma Health Sciences Center)Dharambir K Sanghera(University of Oklahoma Health Sciences Center)Dharambir K Sanghera(University of Oklahoma Health Sciences Center)Stephen M Schwartz(Fred Hutch Cancer Center)Stephen M Schwartz(Fred Hutch Cancer Center)Udo Seedorf(University Medical Center Hamburg-Eppendorf)David J Stott(University of Glasgow)Joachim Thiery(University Hospital Leipzig)Pierre A Zalloua(Lebanese American University)Christopher J O'Donnell(National Heart Lung and Blood Institute)Christopher J O'Donnell(Massachusetts General Hospital)John R Thompson(University of Leicester)Panos Deloukas(William Harvey Research Institute)

View via DOI Full-text PDF

Genetic Associations and Epidemiology RNA modifications and cancer Genetic and phenotypic traits in livestockGenome-wide association studyBiologySingle-nucleotide polymorphismGenetic associationGeneticsImputation (statistics)Coronary artery diseaseMinor allele frequencyGenomeGenetic architecture