article Open AccessTop 1% cited
Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin
New England Journal of Medicine · 2002 · Vol. 346(6) · pp. 393–403
Diabetes Prevention Program Research Group✉(The Coordinating Center)
Abstract
Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin.
Metabolism, Diabetes, and CancerPharmacology and Obesity TreatmentDiabetes, Cardiovascular Risks, and LipoproteinsMetforminMedicineOverweightType 2 diabetesConfidence intervalDiabetes mellitusPlaceboBody mass indexIncidence (geometry)Weight loss
MeSH terms
AdultBlood GlucoseEnergy IntakeDiabetes Mellitus, Type 2Double-Blind MethodFemaleHumansHypoglycemic AgentsLife StyleMaleMetforminMiddle AgedPatient ComplianceRisk FactorsWeight Loss
Citations
18,892
FWCI
252.61
field-weighted impact
References
33
Percentile
100%
vs. same field & year
Citations per year
Cited by
Effectiveness of lifestyle interventions in the prevention of type 2 diabetes mellitus in primary care settings in Saudi Arabia: A systematic review
International Journal of Advanced Community Medicine · 2025 · 0 citations
Effects of integrated diet and exercise interventions on glycaemic regulation in individuals with prediabetes
International Journal of Home Science · 2025 · 0 citations
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
Fertility and Sterility · 2004 · 8,976 citations
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Circulation · 2019 · 6,114 citations
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Circulation · 2019 · 4,494 citations
The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences
Clinical Chemistry · 2008 · 727 citations
Dietary Approaches to Prevent and Treat Hypertension
Hypertension · 2006 · 1,294 citations
Heart Disease and Stroke Statistics—2010 Update
Circulation · 2009 · 5,595 citations
References
Prevalence of Diabetes, Impaired Fasting Glucose, and Impaired Glucose Tolerance in U.S. Adults: The Third National Health and Nutrition Examination Survey, 1988–1994
Diabetes Care · 1998 · 2,725 citations
Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance: The Da Qing IGT and Diabetes Study
Diabetes Care · 1997 · 4,307 citations
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
The Lancet · 1998 · 8,242 citations
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.
The Lancet · 1998 · 8,422 citations
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
New England Journal of Medicine · 2001 · 10,897 citations
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
The Lancet · 1998 · 19,985 citations
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Diabetes Care · 2002 · 10,366 citations
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Diabetes Care · 1997 · 6,207 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.